Hematopoietic Stem Cells Preferentially Traffic Misfolded Proteins to Aggresomes and Depend on Aggrephagy to Maintain Protein Homeostasis.
Chua BA, Lennan CJ, Sunshine M, Dreifke D, Chawla A, Bennett EJ, Signer RAJ.
Cell Stem Cell. 2023;30(4):460-472. Full Text
The Simplified MPP Isolation Scheme: establishing a consensus approach for multipotent progenitor identification.
Challen GA, Pietras EM, Cabezas Wallscheid N, Signer RAJ.
Experimental Hematology. 2021;104:55-63. Full Text
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Kruta M, Sunshine M, Chua BA, Fu Y, Chawla A, Dillingham CH, Hidalgo San Jose L, De Jong B, Zhou FJ, Signer RAJ.
Cell Stem Cell. 2021;28(11):1950-1965. Full Text
Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis.
Magee JA, Signer RAJ.
Stem Cell Reports. 2021;16(1):20-28. Full Text
ERADicating stem cells from their niche.
Lam K, Signer RAJ.
Nature Cell Biology. 2020;22(10):1155-1157. Full Text
Hematopoietic Stem Cell Regulation by the Proteostasis Network.
Chua BA, Signer RAJ.
Current Opinion in Hematology. 2020; 27(4):254-263. Full Text
Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells.
Chua BA, Van Der Werf I, Jamieson C, Signer RAJ.
Cell Stem Cell. 2020; 26(2):138-159. Full Text
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Hidalgo San Jose L, Sunshine M, Dillingham CH, Chua BA, Kruta M, Hong Y, Hatters DM, Signer RAJ.
Cell Reports. 2020; 30(1):69-80. Full Text
Cell-type-specific quantification of protein synthesis in vivo.
Hidalgo San Jose L & Signer RAJ.
Nature Protocols. 2019; 14(2):441-460. Full Text
Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells.
Kruta M & Signer RAJ.
Cell Stem Cell. 2018; 22(3):281-282. Full Text
CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.
Sebastian NT, Zaikos TD, Terry V, Taschuck F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J 4th, Bixby D, Markowitz N, Morrison SJ, Collins KL.
PLoS Pathogens. 2017; 13(7):e1006509. Full Text
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J.
Nature Cell Biology. 2017; 19(6):626-638. Full Text
Distinct Brca1 mutations differentially reduce hematopoietic stem cell function.
Mgbemena VE*, Signer RAJ*, Wijayatunge R, Laxson T, Morrison SJ, Ross TS.
Cell Reports. 2017; 18:947-960. Full Text
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.
Signer RAJ*, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ*.
Genes and Development. 2016; 30:1698-1703. Full Text
Pten cell autonomously modulates the hematopoietic stem cell response to mobilizing cytokines.
Porter SN, Cluster AS, Signer RAJ, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA.
Stem Cell Reports. 2016; 6:806-814. Full Text
Suppression of SWI/SNF component Arid1a promotes mammalian regeneration through chromatin remodeling.
Sun X, Chuang J, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RAJ, Srouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo Y, Wang Z, Xing C, Zhu H.
Cell Stem Cell. 2016; 18:456-466. Full Text
Lens regeneration using endogenous stem cells with gain of visual function.
Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RAJ, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y.
Nature. 2016; 531:323-328. Full Text
Cellular differences in protein synthesis regulate tissue homeostasis.
Buszczak M, Signer RAJ, Morrison SJ.
Cell. 2014; 159:242-251. Full Text
Prospective identification and isolation of functionally distinct populations of neural stem cells and neurosphere-initiating cells in the adult forebrain.
Mich JA*, Signer RAJ*, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ.
eLife. 2014; 10.7554/eLife.02669. Full Text
Haematopoietic stem cells require a highly regulated protein synthesis rate.
Signer RAJ, Magee JA, Salic A, Morrison SJ.
Nature. 2014; 509:49-54. Full Text
Mechanisms that regulate stem cell aging and life span.
Signer RAJ & Morrison SJ.
Cell Stem Cell. 2013; 12:152-165. Full Text
Fibroblast Growth Factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K.
Blood. 2012; 119:5715-5721. Full Text
Immature B cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia.
Signer RAJ*, Montecino-Rodriguez E*, Witte ON, Dorshkind K.
Blood. 2010; 116:2522-2530. Full Text
The ageing immune system: is it ever too old to become young again?
Dorshkind K, Montecino-Rodriguez E, Signer RAJ.
Nature Reviews Immunology. 2009; 9:57-62. Full Text
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
Signer RAJ, Montecino-Rodriguez E, Witte O, Dorshkind K.
Genes and Development. 2008; 22:3115-3120. Full Text
Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.
Signer RAJ, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K.
Blood. 2007; 110:1831-1839. Full Text
Aging, B lymphopoiesis, and patterns of leukemogenesis.
Signer RAJ, Montecino-Rodriguez E, Dorshkind K.
Experimental Gerontology. 2007; 42:391-395. Full Text